Dose and timing of injections for effective cyclosporine A pretreatment before renal ischemia reperfusion in mice

BACKGROUND: There is experimental evidence that lethal ischemia-reperfusion injury (IRI) is largely due to mitochondrial permeability transition pore (mPTP) opening, which can be prevented by cyclosporine A (CsA). The aim of our study is to show that a higher dose of CsA (10 mg/kg) injected just bef...

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Detalles Bibliográficos
Autores principales: Lemoine, Sandrine, Pillot, Bruno, Augeul, Lionel, Rabeyrin, Maud, Varennes, Annie, Normand, Gabrielle, Baetz, Delphine, Ovize, Michel, Juillard, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552114/
https://www.ncbi.nlm.nih.gov/pubmed/28796779
http://dx.doi.org/10.1371/journal.pone.0182358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552114/
https://www.ncbi.nlm.nih.gov/pubmed/28796779
http://dx.doi.org/10.1371/journal.pone.0182358

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