Modeling the human Na(v)1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

Abnormalities in the human Na(v)1.5 (hNa(v)1.5) voltage-gated sodium ion channel (VGSC) are associated with a wide range of cardiac problems and diseases in humans. Current structural models of hNa(v)1.5 are still far from complete and, consequently, their ability to study atomistic interactions of...

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Detalles Bibliográficos
Autores principales: Ahmed, Marawan, Jalily Hasani, Horia, Ganesan, Aravindhan, Houghton, Michael, Barakat, Khaled
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552146/
https://www.ncbi.nlm.nih.gov/pubmed/28831242
http://dx.doi.org/10.2147/DDDT.S133944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552146/
https://www.ncbi.nlm.nih.gov/pubmed/28831242
http://dx.doi.org/10.2147/DDDT.S133944

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