Aβ(42)-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways

Impaired protein clearance likely increases the risk of protein accumulation disorders including Alzheimer’s disease (AD). Protein degradation through the proteasome pathway decreases with age and in AD brains, and the Aβ(42) peptide has been shown to impair proteasome function in cultured cells and...

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Detalles Bibliográficos
Autores principales: Farizatto, Karen L. G., Ikonne, Uzoma S., Almeida, Michael F., Ferrari, Merari F. R., Bahr, Ben A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552263/
https://www.ncbi.nlm.nih.gov/pubmed/28797057
http://dx.doi.org/10.1371/journal.pone.0182895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552263/
https://www.ncbi.nlm.nih.gov/pubmed/28797057
http://dx.doi.org/10.1371/journal.pone.0182895

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