The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases

Infection by enveloped coronaviruses (CoVs) initiates with viral spike (S) proteins binding to cellular receptors, and is followed by proteolytic cleavage of receptor-bound S proteins, which prompts S protein-mediated virus-cell membrane fusion. Infection therefore requires close proximity of recept...

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Detalles Bibliográficos
Autores principales: Earnest, James T., Hantak, Michael P., Li, Kun, McCray, Paul B., Perlman, Stanley, Gallagher, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552337/
https://www.ncbi.nlm.nih.gov/pubmed/28759649
http://dx.doi.org/10.1371/journal.ppat.1006546