New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway

Deep genetic studies revealed that phosphatase and tensin homolog (PTEN) mutations or loss of expression are not early events in cancer development but characterize tumor progression and invasion. Loss of PTEN function causes a full activation of the prosurvival phosphoinositide 3-kinase (PI3K)/AKT/...

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Detalles Bibliográficos
Autores principales: Alfieri, Roberta, Giovannetti, Elisa, Bonelli, Mara, Cavazzoni, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552661/
https://www.ncbi.nlm.nih.gov/pubmed/28848709
http://dx.doi.org/10.3389/fonc.2017.00170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552661/
https://www.ncbi.nlm.nih.gov/pubmed/28848709
http://dx.doi.org/10.3389/fonc.2017.00170

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