Cargando…

New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway

Deep genetic studies revealed that phosphatase and tensin homolog (PTEN) mutations or loss of expression are not early events in cancer development but characterize tumor progression and invasion. Loss of PTEN function causes a full activation of the prosurvival phosphoinositide 3-kinase (PI3K)/AKT/...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alfieri, Roberta, Giovannetti, Elisa, Bonelli, Mara, Cavazzoni, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552661/ https://www.ncbi.nlm.nih.gov/pubmed/28848709 http://dx.doi.org/10.3389/fonc.2017.00170

Ejemplares similares

Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis
por: Blüml, Stephan, et al.
Publicado: (2015)

Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors
por: Xu, Wenting, et al.
Publicado: (2014)

A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancer
por: Lin, Pei-Ching, et al.
Publicado: (2015)

Phosphatase and tensin homolog (PTEN) is down-regulated in human NK/T-cell lymphoma and corrects with clinical outcomes
por: Fu, Xiaorui, et al.
Publicado: (2017)

Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity
por: Wong, J. T., et al.
Publicado: (2006)

Phosphorylation of phosphatase and tensin homolog induced by Helicobacter pylori promotes cell invasion by activation of focal adhesion kinase
por: Yang, Zhen, et al.
Publicado: (2018)

Loss of phosphatase activity in PTEN (phosphatase and tensin homolog deleted on chromosome ten) results in endometrial carcinoma in humans: An in-silico study
por: Mondal, Sunil Kanti, et al.
Publicado: (2020)

Different Conformations of Phosphatase and Tensin Homolog, Deleted on Chromosome 10 (PTEN) Protein within the Nucleus and Cytoplasm of Neurons
por: Moncalero, Vera L., et al.
Publicado: (2011)

Effect of Aging and Dietary Salt and Potassium Intake on Endothelial PTEN (Phosphatase and Tensin Homolog on Chromosome 10) Function
por: Ying, Wei-Zhong, et al.
Publicado: (2012)

Phosphatase and Tensin Homolog (PTEN) Expression as a Surrogate Biomarker Correlated With the Depth of Invasion in Cutaneous Malignant Melanoma
por: Sun, Ziyi, et al.
Publicado: (2023)

Interactions of Phosphatase and Tensin Homologue (PTEN) Proteins with Phosphatidylinositol Phosphates: Insights from Molecular Dynamics Simulations of PTEN and Voltage Sensitive Phosphatase
por: Kalli, Antreas C., et al.
Publicado: (2014)

High miR-718 Suppresses Phosphatase and Tensin Homolog (PTEN) Expression and Correlates to Unfavorable Prognosis in Gastric Cancer
por: Liu, Shufang, et al.
Publicado: (2018)

Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis
por: Tang, Lu, et al.
Publicado: (2017)

Phosphatase and Tensin Homolog (PTEN) of Japanese Flounder—Its Regulation by miRNA and Role in Autophagy, Apoptosis and Pathogen Infection
por: Li, Wenrui, et al.
Publicado: (2020)

Sex differences in skeletal muscle Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: A cross-sectional study
por: Samaan, M. Constantine, et al.
Publicado: (2015)

Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN
por: Cavazzoni, Andrea, et al.
Publicado: (2017)

Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma
por: Zhu, Xuehua, et al.
Publicado: (2012)

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy
por: Abbotts, Rachel, et al.
Publicado: (2014)

Suppression of miR-21 Expression Inhibits Cell Proliferation and Migration of Liver Cancer Cells by Targeting Phosphatase and Tensin Homolog (PTEN)
por: Liu, Haiwei, et al.
Publicado: (2018)

Doxycycline Attenuates Atrial Remodeling by Interfering with MicroRNA-21 and Downstream Phosphatase and Tensin Homolog (PTEN)/Phosphoinositide 3-Kinase (PI3K) Signaling Pathway
por: Zhang, Kai, et al.
Publicado: (2018)

Neuroprotective and Anti-Inflammatory Roles of the Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy
por: Grande, Valentina, et al.
Publicado: (2014)

miR-486 Promotes Capan-2 Pancreatic Cancer Cell Proliferation by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)
por: Xia, Lu, et al.
Publicado: (2019)

Micro-RNA 205-5p is Involved in the Progression of Gastric Cancer and Targets Phosphatase and Tensin Homolog (PTEN) in SGC-7901 Human Gastric Cancer Cells
por: Yao, Lina, et al.
Publicado: (2019)

PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition
por: Cretella, Daniele, et al.
Publicado: (2019)

Knockdown of Phospholipase Cɛ (PLCɛ) Inhibits Cell Proliferation via Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)/AKT Signaling Pathway in Human Prostate Cancer
por: Wang, Xiao, et al.
Publicado: (2018)

Evaluating the value of Amphiregulin, Phosphatase and Tensin Homologue (PTEN) and P21 Expression for Anti-EGFR Treatment in Metastatic Colorectal Carcinoma
por: Obaya, Ahmed Ali, et al.
Publicado: (2021)

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) and PH Domain and Leucine-rich Repeat Phosphatase Cross-talk (PHLPP) in Cancer Cells and in Transforming Growth Factor β-Activated Stem Cells
por: Ghalali, Aram, et al.
Publicado: (2014)

Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas
por: Li, Wenting, et al.
Publicado: (2017)

Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma
por: Liang, Yanfang, et al.
Publicado: (2020)

Expression Profiles of the Phosphatase and Tensin Homolog (PTEN), CDH1, and CDH2 Genes, and the Cell Membrane Protein, CD133, in the Ishikawa Human Endometrial Adenocarcinoma Cell Line
por: Lee, Pingyin, et al.
Publicado: (2019)

The Prognostic Significance of Phosphatase and Tensin Homolog Loss in Breast Cancer
por: Windarti, Indri, et al.
Publicado: (2019)

Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy
por: Tang, Ying, et al.
Publicado: (2015)

Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway
por: Li, Bing-Hui, et al.
Publicado: (2018)

Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles
por: McLaughlin, Marie, et al.
Publicado: (2014)

MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN)
por: Zhou, Weidong, et al.
Publicado: (2014)

MYC-mediated miR-320a affects receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast formation by regulating phosphatase and tensin homolog (PTEN)
por: Chen, Hao, et al.
Publicado: (2021)

Methylation analysis of the phosphates and tensin homologue on chromosome 10 gene (PTEN) in multiple myeloma
por: Piras, Giovanna, et al.
Publicado: (2014)

Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma
por: Liu, Songlin, et al.
Publicado: (2019)

Effects of mir-21 on Cardiac Microvascular Endothelial Cells After Acute Myocardial Infarction in Rats: Role of Phosphatase and Tensin Homolog (PTEN)/Vascular Endothelial Growth Factor (VEGF) Signal Pathway
por: Yang, Feng, et al.
Publicado: (2016)

Focus on PTEN Regulation
por: Bermúdez Brito, Miriam, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_8r9iv7v8c2dcthnjdrog8qn05a