Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control

Drug-antibody ratio (DAR) of antibody-drug conjugates (ADCs) is important for their therapeutic efficacy and pharmacokinetics, therefore control on DAR in synthesis process is a key for ADC quality control. Although various analytical methods were reported, the real-time monitoring on DAR is still a...

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Detalles Bibliográficos
Autores principales: Tang, Yubo, Tang, Feng, Yang, Yang, Zhao, Lei, Zhou, Hu, Dong, Jinhua, Huang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552727/
https://www.ncbi.nlm.nih.gov/pubmed/28798339
http://dx.doi.org/10.1038/s41598-017-08151-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552727/
https://www.ncbi.nlm.nih.gov/pubmed/28798339
http://dx.doi.org/10.1038/s41598-017-08151-2

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