Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism

Angiotensin II (Ang II) promotes hepatic fibrosis by increasing extracellular matrix (ECM) synthesis. Connective tissue growth factor (CTGF) plays a crucial role in the pathogenesis of hepatic fibrosis and emerges as downstream of the profibrogenic cytokine transforming growth factor-β (TGF-β). We a...

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Detalles Bibliográficos
Autores principales: Li, Ao, Zhang, Jingyao, Zhang, Xiaoxun, Wang, Jun, Wang, Songsong, Xiao, Xiao, Wang, Rui, Li, Peng, Wang, Yitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552744/
https://www.ncbi.nlm.nih.gov/pubmed/28798388
http://dx.doi.org/10.1038/s41598-017-08334-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552744/
https://www.ncbi.nlm.nih.gov/pubmed/28798388
http://dx.doi.org/10.1038/s41598-017-08334-x

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