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CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg(−/−) Mice Results in Severe Immunodeficiency
Immunodeficient mice engrafted with either normal or cancerous human cells are widely used in basic and translational research. In particular, NOD/SCID/IL2rg(−/−) mice can support the growth of various types of human cancer cells. However, the hairs of these mice interfere with the observation and i...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552779/ https://www.ncbi.nlm.nih.gov/pubmed/28798321 http://dx.doi.org/10.1038/s41598-017-08337-8 |