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Orthosteric- versus allosteric-dependent activation of the GABA(A) receptor requires numerically distinct subunit level rearrangements
Anaesthetic molecules act on synaptic transmission via the allosteric modulation of ligand-gated chloride channels, such as hetero-oligomeric α(1)β(2)γ(2) GABA(A) receptors. To elucidate the overall activation paradigm via allosteric versus orthosteric sites, we used highly homologous, but homo-olig...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552871/ https://www.ncbi.nlm.nih.gov/pubmed/28798394 http://dx.doi.org/10.1038/s41598-017-08031-9 |