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Monte Carlo simulations of randomized clinical trials in epilepsy
BACKGROUND: The placebo response in epilepsy randomized clinical trials (RCTs) has recently been shown to largely reflect underlying natural variability in seizure frequency. Based on this observation, we sought to explore the parameter space of RCT design to optimize trial efficiency and cost. METH...
Autores principales: | Goldenholz, Daniel M., Tharayil, Joseph, Moss, Robert, Myers, Evan, Theodore, William H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553226/ https://www.ncbi.nlm.nih.gov/pubmed/28812044 http://dx.doi.org/10.1002/acn3.426 |
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