Synergistic Effect of Notch-3-Specific Inhibition and Paclitaxel in Non-Small Cell Lung Cancer (NSCLC) Cells Via Activation of The Intrinsic Apoptosis Pathway

BACKGROUND: Lung cancers are resistant to conventional chemotherapeutic interventions such as paclitaxel. Notch signaling is crucial in the chemoresistance of lung cancer cells. The Notch inhibitor gamma-secretase inhibitor (GSI) inhibits the Notch signaling pathway. MATERIAL/METHODS: Here, we evalu...

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Detalles Bibliográficos
Autores principales: He, Fenglian, Du, Ting, Jiang, Qian, Zhang, Yanbei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553439/
https://www.ncbi.nlm.nih.gov/pubmed/28769027
http://dx.doi.org/10.12659/MSM.902641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553439/
https://www.ncbi.nlm.nih.gov/pubmed/28769027
http://dx.doi.org/10.12659/MSM.902641

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