Cargando…

Synergistic Effect of Notch-3-Specific Inhibition and Paclitaxel in Non-Small Cell Lung Cancer (NSCLC) Cells Via Activation of The Intrinsic Apoptosis Pathway

BACKGROUND: Lung cancers are resistant to conventional chemotherapeutic interventions such as paclitaxel. Notch signaling is crucial in the chemoresistance of lung cancer cells. The Notch inhibitor gamma-secretase inhibitor (GSI) inhibits the Notch signaling pathway. MATERIAL/METHODS: Here, we evalu...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Fenglian, Du, Ting, Jiang, Qian, Zhang, Yanbei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2017
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553439/ https://www.ncbi.nlm.nih.gov/pubmed/28769027 http://dx.doi.org/10.12659/MSM.902641

Ejemplares similares

Specific inhibitor of Notch-3 enhances the sensitivity of NSCLC cells to gemcitabine
por: Hu, Bi-Dan, et al.
Publicado: (2018)

Upregulation of Long Noncoding RNA (lncRNA) X-Inactive Specific Transcript (XIST) is Associated with Cisplatin Resistance in Non-Small Cell Lung Cancer (NSCLC) by Downregulating MicroRNA-144-3p
por: Tian, Lin-Juan, et al.
Publicado: (2019)

Rhizoma Paridis Saponins Induces Cell Cycle Arrest and Apoptosis in Non-Small Cell Lung Carcinoma A549 Cells
por: Zhang, Jue, et al.
Publicado: (2015)

Influence of MiR-451 on Drug Resistances of Paclitaxel-Resistant Breast Cancer Cell Line
por: Gu, Xi, et al.
Publicado: (2015)

Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer Cells
por: Xu, Yimiao, et al.
Publicado: (2011)

Specific Inhibition of β-Catenin in Jeko-1 Mantle Cell Lymphoma Cell Line Decreases Proliferation and Induces Apoptosis
por: He, Jinshui, et al.
Publicado: (2015)

Cell-free genomics reveal intrinsic, cooperative and competitive determinants of chromatin interactions
por: Eggers, Nikolas, et al.
Publicado: (2021)

Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells
por: Jiménez-Guerrero, Rocío, et al.
Publicado: (2018)

Gambogic Acid Induces Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells by Suppressing Notch Signaling
por: Zhu, Minghua, et al.
Publicado: (2018)

Notch Signaling in Meibomian Gland Epithelial Cell Differentiation
por: Gidfar, Sanaz, et al.
Publicado: (2016)

Erlotinib induces the human non–small‐cell lung cancer cells apoptosis via activating ROS‐dependent JNK pathways
por: Shan, Fenglian, et al.
Publicado: (2016)

NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas
por: Meder, Lydia, et al.
Publicado: (2015)

Induced Neural Stem Cells Protect Neuronal Cells against Apoptosis
por: Kim, Jin Hee, et al.
Publicado: (2014)

HLJ1 is a novel caspase-3 substrate and its expression enhances UV-induced apoptosis in non-small cell lung carcinoma
por: Lin, Sheng-Yi, et al.
Publicado: (2010)

Effect of Combined Treatment Using Wilfortrine and Paclitaxel in Liver Cancer and Related Mechanism
por: Li, Shuzhen, et al.
Publicado: (2016)

ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells
por: Parrondo, Ricardo, et al.
Publicado: (2013)

Robustness by intrinsically disordered C-termini and translational readthrough
por: Kleppe, April Snofrid, et al.
Publicado: (2018)

Metformin and 4SC‐202 synergistically promote intrinsic cell apoptosis by accelerating ΔNp63 ubiquitination and degradation in oral squamous cell carcinoma
por: He, Yuan, et al.
Publicado: (2019)

Role of Xeroderma Pigmentosum Group D in Cell Cycle and Apoptosis in Cutaneous Squamous Cell Carcinoma A431 Cells
por: Liu, Ou-Gen, et al.
Publicado: (2018)

Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis
por: Tozluoğlu, Melda, et al.
Publicado: (2008)

Reck-Notch1 Signaling Mediates miR-221/222 Regulation of Lung Cancer Stem Cells in NSCLC
por: Guo, Yuefan, et al.
Publicado: (2021)

The Sineoculis Homeobox Homolog 1 (SIX1) Gene Regulates Paclitaxel Resistance by Affecting Reactive Oxygen Species and Autophagy in Human Hepatocellular Carcinoma Cell Line HepG2
por: Li, Baowei, et al.
Publicado: (2018)

Interferon regulatory factor 4 (IRF4) is overexpressed in human non-small cell lung cancer (NSCLC) and activates the Notch signaling pathway
por: Qian, Yajuan, et al.
Publicado: (2017)

Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
por: Fischer, Andreas, et al.
Publicado: (2007)

Resveratrol Treatment Inhibits Proliferation of and Induces Apoptosis in Human Colon Cancer Cells
por: Feng, Miao, et al.
Publicado: (2016)

Knockdown of CDCA8 inhibits the proliferation and enhances the apoptosis of bladder cancer cells
por: Gao, Xin, et al.
Publicado: (2020)

Ginsenoside panaxatriol reverses TNBC paclitaxel resistance by inhibiting the IRAK1/NF-κB and ERK pathways
por: Wang, Panpan, et al.
Publicado: (2020)

MicroRNA-152 Targets Phosphatase and Tensin Homolog to Inhibit Apoptosis and Promote Cell Migration of Nasopharyngeal Carcinoma Cells
por: Huang, Shunde, et al.
Publicado: (2016)

Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice
por: Masocha, Willias
Publicado: (2015)

Targeting potential receptor molecules in non-small cell lung cancer (NSCLC) using in silico approaches
por: Kirubhanand, C., et al.
Publicado: (2023)

Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice
por: Masocha, Willias
Publicado: (2016)

Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells
por: Trauzold, A, et al.
Publicado: (2003)

Roles of Long Non-Coding RNA CCAT2 in Cervical Cancer Cell Growth and Apoptosis
por: Wu, Le, et al.
Publicado: (2016)

Niacin Suppresses Progression of Atherosclerosis by Inhibiting Vascular Inflammation and Apoptosis of Vascular Smooth Muscle Cells
por: Su, Gang, et al.
Publicado: (2015)

microRNA-25 Inhibits Cell Apoptosis of Human Gastric Adenocarcinoma Cell Line AGS via Regulating CCNE1 and MYC
por: Zhang, Yong, et al.
Publicado: (2016)

MiR-29 Induces K562 Cell Apoptosis by Down-Regulating FoxM1
por: Wang, Xiaofang, et al.
Publicado: (2015)

Synergistic activation of eIF4A by eIF4B and eIF4G
por: Nielsen, Klaus H., et al.
Publicado: (2011)

ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study
por: Luna Velez, Maria V, et al.
Publicado: (2023)

Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC)
por: Rocks, N, et al.
Publicado: (2006)

Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines
por: Zhou, Huanhuan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tb31ek27q54nfitnsgktbpiilc