GENomE wide analysis of sotalol-induced IKr inhibition during ventricular REPOLarization, “GENEREPOL study”: Lack of common variants with large effect sizes

Many drugs used for non-cardiovascular and cardiovascular purposes, such as sotalol, have the side effect of prolonging cardiac repolarization, which can trigger life-threatening cardiac arrhythmias by inhibiting the potassium-channel IKr (KCNH2). On the electrocardiogram (ECG), IKr inhibition induc...

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Detalles Bibliográficos
Autores principales: Salem, Joe-Elie, Germain, Marine, Hulot, Jean-Sébastien, Voiriot, Pascal, Lebourgeois, Bruno, Waldura, Jean, Tregouet, David-Alexandre, Charbit, Beny, Funck-Brentano, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553738/
https://www.ncbi.nlm.nih.gov/pubmed/28800628
http://dx.doi.org/10.1371/journal.pone.0181875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553738/
https://www.ncbi.nlm.nih.gov/pubmed/28800628
http://dx.doi.org/10.1371/journal.pone.0181875

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