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Angiopoietin-1 deficiency increases tumor metastasis in mice

BACKGROUND: Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. Here, we test the hypothesis that l...

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Detalles Bibliográficos
Autores principales: Michael, Iacovos P., Orebrand, Martina, Lima, Marta, Pereira, Beatriz, Volpert, Olga, Quaggin, Susan E., Jeansson, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553747/
https://www.ncbi.nlm.nih.gov/pubmed/28800750
http://dx.doi.org/10.1186/s12885-017-3531-y