Highly efficient gene inactivation by adenoviral CRISPR/Cas9 in human primary cells

Phenotypic assays using human primary cells are highly valuable tools for target discovery and validation in drug discovery. Expression knockdown (KD) of such targets in these assays allows the investigation of their role in models of disease processes. Therefore, efficient and fast modes of protein...

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Detalles Bibliográficos
Autores principales: Voets, Olaf, Tielen, Frans, Elstak, Edo, Benschop, Julian, Grimbergen, Max, Stallen, Jan, Janssen, Richard, van Marle, Andre, Essrich, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553774/
https://www.ncbi.nlm.nih.gov/pubmed/28800587
http://dx.doi.org/10.1371/journal.pone.0182974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553774/
https://www.ncbi.nlm.nih.gov/pubmed/28800587
http://dx.doi.org/10.1371/journal.pone.0182974

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