Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder

BACKGROUND: Major depressive disorder (MDD) is the second largest cause of global disease burden. It has an estimated heritability of 37%, but published genome-wide association studies have so far identified few risk loci. Haplotype-block-based regional heritability mapping (HRHM) estimates the loca...

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Detalles Bibliográficos
Autores principales: Zeng, Yanni, Navarro, Pau, Shirali, Masoud, Howard, David M., Adams, Mark J., Hall, Lynsey S., Clarke, Toni-Kim, Thomson, Pippa A., Smith, Blair H., Murray, Alison, Padmanabhan, Sandosh, Hayward, Caroline, Boutin, Thibaud, MacIntyre, Donald J., Lewis, Cathryn M., Wray, Naomi R., Mehta, Divya, Penninx, Brenda W.J.H., Milaneschi, Yuri, Baune, Bernhard T., Air, Tracy, Hottenga, Jouke-Jan, Mbarek, Hamdi, Castelao, Enrique, Pistis, Giorgio, Schulze, Thomas G., Streit, Fabian, Forstner, Andreas J., Byrne, Enda M., Martin, Nicholas G., Breen, Gerome, Müller-Myhsok, Bertram, Lucae, Susanne, Kloiber, Stefan, Domenici, Enrico, Deary, Ian J., Porteous, David J., Haley, Chris S., McIntosh, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Priority Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553996/
https://www.ncbi.nlm.nih.gov/pubmed/28153336
http://dx.doi.org/10.1016/j.biopsych.2016.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553996/
https://www.ncbi.nlm.nih.gov/pubmed/28153336
http://dx.doi.org/10.1016/j.biopsych.2016.12.012

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