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β(1)-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes
β(1)-adrenergic receptors (β(1)ARs) mediate catecholamine actions in cardiomyocytes by coupling to both Gs/cAMP-dependent and Gs-independent/growth-regulatory pathways. Structural studies of the β(1)AR define ligand-binding sites in the transmembrane helices and effector docking sites at the intrace...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554155/ https://www.ncbi.nlm.nih.gov/pubmed/28801655 http://dx.doi.org/10.1038/s41598-017-06607-z |