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β(1)-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes

β(1)-adrenergic receptors (β(1)ARs) mediate catecholamine actions in cardiomyocytes by coupling to both Gs/cAMP-dependent and Gs-independent/growth-regulatory pathways. Structural studies of the β(1)AR define ligand-binding sites in the transmembrane helices and effector docking sites at the intrace...

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Detalles Bibliográficos
Autores principales:	Park, Misun, Reddy, Gopireddy R., Wallukat, Gerd, Xiang, Yang K., Steinberg, Susan F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554155/ https://www.ncbi.nlm.nih.gov/pubmed/28801655 http://dx.doi.org/10.1038/s41598-017-06607-z

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