Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis

A recent study of the RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase in efficacy from 50–60% to 80% when using a delayed fractional dose regimen, in which the standard 0–1–2 month immunization schedule was modified to a 0–1–7 month schedule and...

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Detalles Bibliográficos
Autores principales: Chaudhury, Sidhartha, Regules, Jason A., Darko, Christian A., Dutta, Sheetij, Wallqvist, Anders, Waters, Norman C., Jongert, Erik, Lemiale, Franck, Bergmann-Leitner, Elke S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554171/
https://www.ncbi.nlm.nih.gov/pubmed/28801554
http://dx.doi.org/10.1038/s41598-017-08526-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554171/
https://www.ncbi.nlm.nih.gov/pubmed/28801554
http://dx.doi.org/10.1038/s41598-017-08526-5

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