Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice

2-methoxyestradiol (2-ME), an estrogen metabolite generated via catechol-o-methyltransferase (COMT), is multifunctional methoxy-catechol. Here, we report that COMT deficiency leads to glucose intolerance and 2-ME rescues COMT-deficient-associated metabolic defects. Liver COMT protein was suppressed...

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Detalles Bibliográficos
Autores principales: Kanasaki, Megumi, Srivastava, Swayam Prakash, Yang, Fan, Xu, Ling, Kudoh, Sumiyo, Kitada, Munehiro, Ueki, Norikazu, Kim, Hyoh, Li, Jinpeng, Takeda, Satoru, Kanasaki, Keizo, Koya, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554180/
https://www.ncbi.nlm.nih.gov/pubmed/28801594
http://dx.doi.org/10.1038/s41598-017-08513-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554180/
https://www.ncbi.nlm.nih.gov/pubmed/28801594
http://dx.doi.org/10.1038/s41598-017-08513-w

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