The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural determinants for the anti-silencing function

Suppression of therapeutic transgene expression from retroviral gene therapy vectors by epigenetic defence mechanisms represents a problem that is particularly encountered in pluripotent stem cells (PSCs) and their differentiated progeny. Transgene expression in these cells, however, can be stabilis...

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Detalles Bibliográficos
Autores principales: Kunkiel, Jessica, Gödecke, Natascha, Ackermann, Mania, Hoffmann, Dirk, Schambach, Axel, Lachmann, Nico, Wirth, Dagmar, Moritz, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554207/
https://www.ncbi.nlm.nih.gov/pubmed/28801671
http://dx.doi.org/10.1038/s41598-017-04212-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554207/
https://www.ncbi.nlm.nih.gov/pubmed/28801671
http://dx.doi.org/10.1038/s41598-017-04212-8

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