G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning

Biased agonism at G protein coupled receptors emerges as an opportunity for development of drugs with enhanced benefit/risk balance making biased ligand identification a priority. However, ligand biased signature, classically inferred from ligand activity across multiple pathways, displays high vari...

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Detalles Bibliográficos
Autores principales: Onfroy, Lauriane, Galandrin, Ségolène, Pontier, Stéphanie M., Seguelas, Marie-Hélène, N’Guyen, Du, Sénard, Jean-Michel, Galés, Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554226/
https://www.ncbi.nlm.nih.gov/pubmed/28801617
http://dx.doi.org/10.1038/s41598-017-07392-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554226/
https://www.ncbi.nlm.nih.gov/pubmed/28801617
http://dx.doi.org/10.1038/s41598-017-07392-5

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