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G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning
Biased agonism at G protein coupled receptors emerges as an opportunity for development of drugs with enhanced benefit/risk balance making biased ligand identification a priority. However, ligand biased signature, classically inferred from ligand activity across multiple pathways, displays high vari...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554226/ https://www.ncbi.nlm.nih.gov/pubmed/28801617 http://dx.doi.org/10.1038/s41598-017-07392-5 |