Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH

Gliomas maintain an acidic extracellular pH (pH(e)), which promotes tumor growth and builds resistance to therapy. Given evidence that acidic pH(e) beyond the tumor core indicates infiltration, we hypothesized that imaging the intratumoral pH(e) in relation to the peritumoral pH(e) can provide a nov...

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Detalles Bibliográficos
Autores principales: Rao, Jyotsna U., Coman, Daniel, Walsh, John J., Ali, Meser M., Huang, Yuegao, Hyder, Fahmeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554228/
https://www.ncbi.nlm.nih.gov/pubmed/28801587
http://dx.doi.org/10.1038/s41598-017-07609-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554228/
https://www.ncbi.nlm.nih.gov/pubmed/28801587
http://dx.doi.org/10.1038/s41598-017-07609-7

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