Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer

Pancreatic tumors are renowned for their extremely hypoxic centers, resulting in upregulation of a number of hypoxia mediated signaling pathways including cell proliferation, metabolism and cell survival. Previous studies from our laboratory have shown that Minnelide, a water-soluble pro-drug of tri...

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Detalles Bibliográficos
Autores principales: McGinn, Olivia, Gupta, Vineet K., Dauer, Patricia, Arora, Nivedita, Sharma, Nikita, Nomura, Alice, Dudeja, Vikas, Saluja, Ashok, Banerjee, Sulagna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554238/
https://www.ncbi.nlm.nih.gov/pubmed/28801636
http://dx.doi.org/10.1038/s41598-017-08447-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554238/
https://www.ncbi.nlm.nih.gov/pubmed/28801636
http://dx.doi.org/10.1038/s41598-017-08447-3

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