AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson’s Disease

Afadin 6 (AF-6) is an F-actin binding multidomain-containing scaffolding protein that is known for its function in cell-cell adhesion. Interestingly, besides this well documented role, we recently found that AF-6 is a Parkin-interacting protein that augments Parkin/PINK1-mediated mitophagy. Notably,...

Descripción completa

Detalles Bibliográficos
Autores principales: Basil, Adeline H., Sim, Joan P. L., Lim, Grace G. Y., Lin, Shuping, Chan, Hui Ying, Engelender, Simone, Lim, Kah-Leong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554356/
https://www.ncbi.nlm.nih.gov/pubmed/28848400
http://dx.doi.org/10.3389/fncel.2017.00241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554356/
https://www.ncbi.nlm.nih.gov/pubmed/28848400
http://dx.doi.org/10.3389/fncel.2017.00241

Ejemplares similares