N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms

[Image: see text] A series of N-acylbenzenesulfonamide dihydro-1,3,4-oxadiazole hybrids (EMAC8000a–m) was designed and synthesized with the aim to target tumor associated carbonic anhydrase (hCA) isoforms IX and XII. Most of the compounds were selective inhibitors of the tumor associated hCA XII. Mo...

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Detalles Bibliográficos
Autores principales: Bianco, Giulia, Meleddu, Rita, Distinto, Simona, Cottiglia, Filippo, Gaspari, Marco, Melis, Claudia, Corona, Angela, Angius, Rossella, Angeli, Andrea, Taverna, Domenico, Alcaro, Stefano, Leitans, Janis, Kazaks, Andris, Tars, Kaspars, Supuran, Claudiu T., Maccioni, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554910/
https://www.ncbi.nlm.nih.gov/pubmed/28835790
http://dx.doi.org/10.1021/acsmedchemlett.7b00205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554910/
https://www.ncbi.nlm.nih.gov/pubmed/28835790
http://dx.doi.org/10.1021/acsmedchemlett.7b00205

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