NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin

Thioridazine is known to have anti-tumor effects by inhibiting PI3K/Akt signaling, which is an important signaling pathway in cell survival. However, thioridazine alone does not induce apoptosis in head and neck squamous cell carcinoma (AMC-HN4), human breast carcinoma (MDA-MB231), and human glioma...

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Detalles Bibliográficos
Autores principales: Seo, Seung Un, Kim, Tae Hwan, Kim, Dong Eun, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554966/
https://www.ncbi.nlm.nih.gov/pubmed/28806703
http://dx.doi.org/10.1016/j.redox.2017.07.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554966/
https://www.ncbi.nlm.nih.gov/pubmed/28806703
http://dx.doi.org/10.1016/j.redox.2017.07.017

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