Cargando…

Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome

Loss-of-function mutations in SCN1A cause Dravet syndrome (DS), a catastrophic childhood epilepsy in which patients experience comorbid behavioral conditions, including movement disorders, sleep abnormalities, anxiety, and intellectual disability. To study the functional consequences of voltage-gate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grone, Brian P., Qu, Tiange, Baraban, Scott C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2017
Materias:	New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555352/ https://www.ncbi.nlm.nih.gov/pubmed/28812061 http://dx.doi.org/10.1523/ENEURO.0066-17.2017

Ejemplares similares

Drug repurposing for Dravet syndrome in scn1Lab (−/−) mutant zebrafish
por: Sourbron, Jo, et al.
Publicado: (2019)

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet Syndrome treatment
por: Baraban, Scott C., et al.
Publicado: (2013)

Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome1,2,3
por: Dinday, Matthew T., et al.
Publicado: (2015)

Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome123
por: Kumar, Maneesh G., et al.
Publicado: (2016)

Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening
por: Griffin, Aliesha, et al.
Publicado: (2018)

Stiripentol for Dravet syndrome
Publicado: (2020)

Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model
por: Griffin, Aliesha, et al.
Publicado: (2020)

Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome
por: Banerji, Rajeswari, et al.
Publicado: (2021)

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome
por: Griffin, Aliesha L, et al.
Publicado: (2019)

Cannabidiol for epilepsy (Lennox-Gastaut syndrome, Dravet syndrome)
Publicado: (2020)

SCN1B and SCN2B gene variants analysis in dravet syndrome patients: Analysis of 22 cases
por: Gong, Jiao-E., et al.
Publicado: (2019)

Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation
por: Ricobaraza, Ana, et al.
Publicado: (2019)

Efficacy of Stiripentol in Dravet Syndrome with or without SCN1A Mutations
por: Cho, Min Jung, et al.
Publicado: (2018)

Dravet syndrome: a new causative SCN1A mutation?
por: Poryo, Martin, et al.
Publicado: (2017)

Ictal vocalizations in the Scn1a (+/−) mouse model of Dravet syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2023)

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome
por: Yuan, Yukun, et al.
Publicado: (2019)

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome
por: Lenk, Guy M., et al.
Publicado: (2020)

Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in the Scn1a Haploinsufficiency Mouse Model of Dravet Syndrome
por: Chancey, Jessica Hotard, et al.
Publicado: (2022)

Network Properties Revealed during Multi-Scale Calcium Imaging of Seizure Activity in Zebrafish
por: Liu, Jing, et al.
Publicado: (2019)

Epilepsy, Behavioral Abnormalities, and Physiological Comorbidities in Syntaxin-Binding Protein 1 (STXBP1) Mutant Zebrafish
por: Grone, Brian P., et al.
Publicado: (2016)

Dravet Syndrome in Lebanon: First Report on Cases with SCN1A Mutations
por: Alame, Saada, et al.
Publicado: (2019)

Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome
por: Ritter-Makinson, Stefanie, et al.
Publicado: (2019)

Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome
por: Ritter-Makinson, Stefanie, et al.
Publicado: (2019)

TANGO With SCN1A: Can This Molecular Dance Defeat Dravet Syndrome?
por: Wagnon, Jacy L.
Publicado: (2020)

Author Correction: Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation
por: Ricobaraza, Ana, et al.
Publicado: (2021)

Identification of SCN1A and PCDH19 Mutations in Chinese Children with Dravet Syndrome
por: Kwong, Anna Ka-Yee, et al.
Publicado: (2012)

Morphometry and network-based atrophy patterns in SCN1A-related Dravet syndrome
por: Lenge, Matteo, et al.
Publicado: (2023)

SCN1A Genetic Test for Dravet Syndrome (Severe Myoclonic Epilepsy of Infancy and its Clinical Subtypes) for use in the Diagnosis, Prognosis, Treatment and Management of Dravet Syndrome
por: Stenhouse, Susan A.R., et al.
Publicado: (2013)

Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations
por: Mora-Jimenez, Lucia, et al.
Publicado: (2021)

SCN1A Gene Mutation and Adaptive Functioning in 18 Vietnamese Children with Dravet Syndrome
por: Do, Thi Thu Hang, et al.
Publicado: (2017)

SCN1A Mutation—Beyond Dravet Syndrome: A Systematic Review and Narrative Synthesis
por: Ding, Jiangwei, et al.
Publicado: (2021)

Acute effect of antiseizure drugs on background oscillations in Scn1a (A1783V) Dravet syndrome mouse model
por: Quinn, Shir, et al.
Publicado: (2023)

Altered Channel Conductance States and Gating of GABA(A) Receptors by a Pore Mutation Linked to Dravet Syndrome
por: Hernandez, Ciria C., et al.
Publicado: (2017)

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a (+/−) Mouse Model of Dravet Syndrome
por: Satpute Janve, Vaishali, et al.
Publicado: (2021)

Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype
por: Sadleir, Lynette G., et al.
Publicado: (2017)

Multimodal Analysis of SCN1A Missense Variants Improves Interpretation of Clinically Relevant Variants in Dravet Syndrome
por: Gonsales, Marina C., et al.
Publicado: (2019)

Beyond Dravet Syndrome: Characterization of a Novel, More Severe SCN1A-Linked Epileptic Encephalopathy
por: Beck, Veronica C., et al.
Publicado: (2019)

The dose makes the poison—Novel insights into Dravet syndrome and SCN1A regulation through nonproductive splicing
por: Helbig, Ingo, et al.
Publicado: (2021)

Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome
por: Li, Jing, et al.
Publicado: (2021)

Dravet syndrome
por: Incorpora, Gemma
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_k7pp0lfin5kmhgebgfhe0gbs0b