A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies in Drosophila melanogaster

A gain-of-function mutation in the tyrosine kinase JAK2 (JAK2(V617F)) causes human myeloproliferative neoplasms (MPNs). These patients present with high numbers of myeloid lineage cells and have numerous complications. Since current MPN therapies are not curative, there is a need to find new regulat...

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Detalles Bibliográficos
Autores principales: Anderson, Abigail M., Bailetti, Alessandro A., Rodkin, Elizabeth, De, Atish, Bach, Erika A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Mutant Screen Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555452/
https://www.ncbi.nlm.nih.gov/pubmed/28620086
http://dx.doi.org/10.1534/g3.117.044172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555452/
https://www.ncbi.nlm.nih.gov/pubmed/28620086
http://dx.doi.org/10.1534/g3.117.044172

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