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RNA Phase Transitions in Repeat Expansion Disorders

Expansions of short nucleotide repeats produce several neurological and neuromuscular disorders including Huntington’s disease, muscular dystrophy and amyotrophic lateral sclerosis. A common pathological feature of these diseases is the accumulation of the repeat containing transcripts into aberrant...

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Detalles Bibliográficos
Autores principales: Jain, Ankur, Vale, Ronald D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555642/
https://www.ncbi.nlm.nih.gov/pubmed/28562589
http://dx.doi.org/10.1038/nature22386