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Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy
Altered cellular lipid composition activates the endoplasmic reticulum unfolded protein response (UPR), and UPR signaling effects important changes in lipid metabolism. Secondary effects on protein folding homeostasis likely contribute to UPR activation, but deletion of the unfolded protein stress-s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555659/ https://www.ncbi.nlm.nih.gov/pubmed/28615323 http://dx.doi.org/10.1091/mbc.E17-03-0144 |