XOR inhibition with febuxostat accelerates pulmonary endothelial barrier recovery and improves survival in lipopolysaccharide‐induced murine sepsis

Sepsis is a leading cause of death among patients in the intensive care unit, resulting from multi‐organ failure. Activity of xanthine oxidoreductase (XOR), a reactive oxygen species (ROS) producing enzyme, is known to be elevated in nonsurvivors of sepsis compared to survivors. We have previously d...

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Detalles Bibliográficos
Autores principales: Damarla, Mahendra, Johnston, Laura F., Liu, Gigi, Gao, Li, Wang, Lan, Varela, Lidenys, Kolb, Todd M., Kim, Bo S., Damico, Rachel L., Hassoun, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555900/
https://www.ncbi.nlm.nih.gov/pubmed/28801519
http://dx.doi.org/10.14814/phy2.13377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555900/
https://www.ncbi.nlm.nih.gov/pubmed/28801519
http://dx.doi.org/10.14814/phy2.13377

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