Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation

Proteostasis alteration and neuroinflammation are typical features of normal aging. We have previously shown that neuroinflammation alters cellular proteostasis through immunoproteasome induction, leading to a transient decrease of proteasome activity. Here, we further investigated the role of acute...

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Detalles Bibliográficos
Autores principales: Pintado, Cristina, Macías, Sandra, Domínguez-Martín, Helena, Castaño, Angélica, Ruano, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556015/
https://www.ncbi.nlm.nih.gov/pubmed/28808322
http://dx.doi.org/10.1038/s41598-017-08722-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556015/
https://www.ncbi.nlm.nih.gov/pubmed/28808322
http://dx.doi.org/10.1038/s41598-017-08722-3

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