Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners

CAS is a docking protein downstream of the proto-oncogene Src with a role in invasion and metastasis of cancer cells. The CAS SH3 domain is indispensable for CAS-mediated signaling, but structural aspects of CAS SH3 ligand binding and regulation are not well understood. Here, we identified the conse...

Descripción completa

Detalles Bibliográficos
Autores principales: Gemperle, Jakub, Hexnerová, Rozálie, Lepšík, Martin, Tesina, Petr, Dibus, Michal, Novotný, Marian, Brábek, Jan, Veverka, Václav, Rosel, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556061/
https://www.ncbi.nlm.nih.gov/pubmed/28808245
http://dx.doi.org/10.1038/s41598-017-08303-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556061/
https://www.ncbi.nlm.nih.gov/pubmed/28808245
http://dx.doi.org/10.1038/s41598-017-08303-4

Ejemplares similares