ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways

Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ataxia telangiectasia and Rad3-related protein...

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Detalles Bibliográficos
Autores principales: Le, Thuc M., Poddar, Soumya, Capri, Joseph R., Abt, Evan R., Kim, Woosuk, Wei, Liu, Uong, Nhu T., Cheng, Chloe M., Braas, Daniel, Nikanjam, Mina, Rix, Peter, Merkurjev, Daria, Zaretsky, Jesse, Kornblum, Harley I., Ribas, Antoni, Herschman, Harvey R., Whitelegge, Julian, Faull, Kym F., Donahue, Timothy R., Czernin, Johannes, Radu, Caius G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556071/
https://www.ncbi.nlm.nih.gov/pubmed/28808226
http://dx.doi.org/10.1038/s41467-017-00221-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556071/
https://www.ncbi.nlm.nih.gov/pubmed/28808226
http://dx.doi.org/10.1038/s41467-017-00221-3

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