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ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ataxia telangiectasia and Rad3-related protein...
Autores principales: | Le, Thuc M., Poddar, Soumya, Capri, Joseph R., Abt, Evan R., Kim, Woosuk, Wei, Liu, Uong, Nhu T., Cheng, Chloe M., Braas, Daniel, Nikanjam, Mina, Rix, Peter, Merkurjev, Daria, Zaretsky, Jesse, Kornblum, Harley I., Ribas, Antoni, Herschman, Harvey R., Whitelegge, Julian, Faull, Kym F., Donahue, Timothy R., Czernin, Johannes, Radu, Caius G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556071/ https://www.ncbi.nlm.nih.gov/pubmed/28808226 http://dx.doi.org/10.1038/s41467-017-00221-3 |
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