Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters

Resistance-Nodulation-cell Division (RND) transporters AcrB and AcrD of Escherichia coli expel a wide range of substrates out of the cell in conjunction with AcrA and TolC, contributing to the onset of bacterial multidrug resistance. Despite sharing an overall sequence identity of ~66% (similarity ~...

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Detalles Bibliográficos
Autores principales: Ramaswamy, Venkata Krishnan, Vargiu, Attilio V., Malloci, Giuliano, Dreier, Jürg, Ruggerone, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556075/
https://www.ncbi.nlm.nih.gov/pubmed/28808284
http://dx.doi.org/10.1038/s41598-017-08747-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556075/
https://www.ncbi.nlm.nih.gov/pubmed/28808284
http://dx.doi.org/10.1038/s41598-017-08747-8

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