Tumor microenvironment conditions alter Akt and Na(+)/H(+) exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer

BACKGROUND: Chronic angiogenesis is a hallmark of most tumors and takes place in a hostile tumor microenvironment (TME) characterized by hypoxia, low nutrient and glucose levels, elevated lactate and low pH. Despite this, most studies addressing angiogenic signaling use hypoxia as a proxy for tumor...

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Detalles Bibliográficos
Autores principales: Pedersen, A. K., Mendes Lopes de Melo, J., Mørup, N., Tritsaris, K., Pedersen, S. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556346/
https://www.ncbi.nlm.nih.gov/pubmed/28806945
http://dx.doi.org/10.1186/s12885-017-3532-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556346/
https://www.ncbi.nlm.nih.gov/pubmed/28806945
http://dx.doi.org/10.1186/s12885-017-3532-x

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