Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

BACKGROUND: Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk ca...

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Detalles Bibliográficos
Autores principales: Li, Yin, Wang, Yan, Zhou, Yong, Li, Jie, Chen, Kai, Zhang, Leisi, Deng, Manman, Deng, Suqi, Li, Peng, Xu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556349/
https://www.ncbi.nlm.nih.gov/pubmed/28814980
http://dx.doi.org/10.1186/s13148-017-0377-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556349/
https://www.ncbi.nlm.nih.gov/pubmed/28814980
http://dx.doi.org/10.1186/s13148-017-0377-8

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