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Connectivity, not region-intrinsic properties, predicts regional vulnerability to progressive tau pathology in mouse models of disease
Spatiotemporal tau pathology progression is regarded as highly stereotyped within each type of degenerative condition. For instance, AD has a progression of tau pathology consistently beginning in the entorhinal cortex, the locus coeruleus, and other nearby noradrenergic brainstem nuclei, before spr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556602/ https://www.ncbi.nlm.nih.gov/pubmed/28807028 http://dx.doi.org/10.1186/s40478-017-0459-z |