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Understanding the cluster randomised crossover design: a graphical illustraton of the components of variation and a sample size tutorial

BACKGROUND: In a cluster randomised crossover (CRXO) design, a sequence of interventions is assigned to a group, or ‘cluster’ of individuals. Each cluster receives each intervention in a separate period of time, forming ‘cluster-periods’. Sample size calculations for CRXO trials need to account for...

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Detalles Bibliográficos
Autores principales: Arnup, Sarah J., McKenzie, Joanne E., Hemming, Karla, Pilcher, David, Forbes, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557529/
https://www.ncbi.nlm.nih.gov/pubmed/28810895
http://dx.doi.org/10.1186/s13063-017-2113-2