RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

A pair of kinases, RIPK1 and RIPK3, as well as the RIPK3 substrate MLKL cause a form of programmed necrotic cell death in mammals termed necroptosis. We report here that male reproductive organs of both Ripk3- and Mlkl-knockout mice retain ‘youthful’ morphology and function into advanced age, while...

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Detalles Bibliográficos
Autores principales: Li, Dianrong, Meng, Lingjun, Xu, Tao, Su, Yaning, Liu, Xiao, Zhang, Zhiyuan, Wang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557593/
https://www.ncbi.nlm.nih.gov/pubmed/28807105
http://dx.doi.org/10.7554/eLife.27692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557593/
https://www.ncbi.nlm.nih.gov/pubmed/28807105
http://dx.doi.org/10.7554/eLife.27692

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