Epistatic Interactions within the Influenza A Virus Polymerase Complex Mediate Mutagen Resistance and Replication Fidelity

Lethal mutagenesis is a broad-spectrum antiviral strategy that employs mutagenic nucleoside analogs to exploit the high mutation rate and low mutational tolerance of many RNA viruses. Studies of mutagen-resistant viruses have identified determinants of replicative fidelity and the importance of muta...

Descripción completa

Detalles Bibliográficos
Autores principales: Pauly, Matthew D., Lyons, Daniel M., Fitzsimmons, William J., Lauring, Adam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557677/
https://www.ncbi.nlm.nih.gov/pubmed/28815216
http://dx.doi.org/10.1128/mSphere.00323-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557677/
https://www.ncbi.nlm.nih.gov/pubmed/28815216
http://dx.doi.org/10.1128/mSphere.00323-17

Ejemplares similares