Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case

Bitter taste is one of the basic taste modalities, warning against consuming potential poisons. Bitter compounds activate members of the bitter taste receptor (Tas2r) subfamily of G protein-coupled receptors (GPCRs). The number of functional Tas2rs is species-dependent. Chickens represent an intrigu...

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Detalles Bibliográficos
Autores principales: Di Pizio, Antonella, Kruetzfeldt, Louisa-Marie, Cheled-Shoval, Shira, Meyerhof, Wolfgang, Behrens, Maik, Niv, Masha Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557796/
https://www.ncbi.nlm.nih.gov/pubmed/28811548
http://dx.doi.org/10.1038/s41598-017-08344-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557796/
https://www.ncbi.nlm.nih.gov/pubmed/28811548
http://dx.doi.org/10.1038/s41598-017-08344-9

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