Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

In vitro models that better reflect in vivo epithelial barrier (patho-)physiology are urgently required to predict adverse drug effects. Here we introduce extracellular matrix-supported intestinal tubules in perfused microfluidic devices, exhibiting tissue polarization and transporter expression. Fo...

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Detalles Bibliográficos
Autores principales: Trietsch, Sebastiaan J., Naumovska, Elena, Kurek, Dorota, Setyawati, Meily C., Vormann, Marianne K., Wilschut, Karlijn J., Lanz, Henriëtte L., Nicolas, Arnaud, Ng, Chee Ping, Joore, Jos, Kustermann, Stefan, Roth, Adrian, Hankemeier, Thomas, Moisan, Annie, Vulto, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557798/
https://www.ncbi.nlm.nih.gov/pubmed/28811479
http://dx.doi.org/10.1038/s41467-017-00259-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557798/
https://www.ncbi.nlm.nih.gov/pubmed/28811479
http://dx.doi.org/10.1038/s41467-017-00259-3

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