PAFAH1B1 haploinsufficiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus

Hemizygous mutations in the human gene encoding platelet-activating factor acetylhydrolase IB subunit alpha (Pafah1b1), also called Lissencephaly-1, can cause classical lissencephaly, a severe malformation of cortical development. Children with this disorder suffer from deficits in neuronal migratio...

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Detalles Bibliográficos
Autores principales: Dinday, Matthew T., Girskis, Kelly M., Lee, Sunyoung, Baraban, Scott C., Hunt, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557934/
https://www.ncbi.nlm.nih.gov/pubmed/28811646
http://dx.doi.org/10.1038/s41598-017-08809-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557934/
https://www.ncbi.nlm.nih.gov/pubmed/28811646
http://dx.doi.org/10.1038/s41598-017-08809-x

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