Forces and Disease: Electrostatic force differences caused by mutations in kinesin motor domains can distinguish between disease-causing and non-disease-causing mutations

The ability to predict if a given mutation is disease-causing or not has enormous potential to impact human health. Typically, these predictions are made by assessing the effects of mutation on macromolecular stability and amino acid conservation. Here we report a novel feature: the electrostatic co...

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Detalles Bibliográficos
Autores principales: Li, Lin, Jia, Zhe, Peng, Yunhui, Godar, Subash, Getov, Ivan, Teng, Shaolei, Alper, Joshua, Alexov, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557957/
https://www.ncbi.nlm.nih.gov/pubmed/28811629
http://dx.doi.org/10.1038/s41598-017-08419-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557957/
https://www.ncbi.nlm.nih.gov/pubmed/28811629
http://dx.doi.org/10.1038/s41598-017-08419-7

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