The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity

Post-transcriptional modifications can control protein abundance, but the extent to which these alterations contribute to the expression of T helper (T(H)) lineage-defining factors is unknown. Tight regulation of Bcl6 expression, an essential transcription factor for T follicular helper (T(FH)) cell...

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Detalles Bibliográficos
Autores principales: Yi, Woelsung, Gupta, Sanjay, Ricker, Edd, Manni, Michela, Jessberger, Rolf, Chinenov, Yurii, Molina, Henrik, Pernis, Alessandra B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557982/
https://www.ncbi.nlm.nih.gov/pubmed/28811467
http://dx.doi.org/10.1038/s41467-017-00348-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557982/
https://www.ncbi.nlm.nih.gov/pubmed/28811467
http://dx.doi.org/10.1038/s41467-017-00348-3

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